The ARC C3MB is a collaborative research initiative of the INRIA between 4 laboratories: the vectorology team of the CNRS at the Institut Gustave Roussy (Villejuif), the Laboratoire de Mathématiques de Versailles and the INRIA teams NUMED (Lyon) and MC2 (Bordeaux).

Presentation of the ARC C3MB

The aim of this project is to propose a comprehensive study of the modeling of tumor growth, including submicroscopic (molecular level), microscopic (cell level) and macroscopic (tissues and organ level) elements and to apply these modeling tools to therapeutic innovation in oncology. The long-term goal is to improve drug delivery protocols for clinical trial. This crucial aim requires as a first step the mathematical analysis and control of complex multiscale models of tumor growth. To focus our work, we propose to target two precise applications: combination of anti-angiogenesis drugs with chemotherapy in the treatment of colorectal cancers and electro-chemotherapies for brain tumors.
The main points that we want to address are the following:
1) This problem is clearly a multiscale problem and each level has to be treated separately before to be integrating in a complete model.
2) In order to be useful for therapeutic innovation, one needs some data that can be obtained from in vitro, in vivo, or clinical experiments including medical imaging.
3) Finally, some low order (simple) models are needed for the clinical trials.
See the detailled project (in french)
See the poster (in french)


Vectorology and Anticancer Therapies, UMR 8203, Institut Gustave Roussy (Villejuif, France)
INRIA Team MC2 (Bordeaux, France)
INRIA Team NUMED (Lyon, France)
Laboratoire de Mathématiques de Versailles (Versailles, France)


Thierry Colin
Team MC2
INRIA Bordeaux-Sud-Ouest
351, cours de la Libération
33 405 TALENCE cedex, FRANCE